Gender differences in cadmium and cotinine levels in prepubertal children [* Cross-Reference *]

Version 1.0

Fucic, A.; Plavec, D.; Casteleyn, L.; Aerts, D.; Biot, P.; Katsonouri, A.; Cerna, M.; Knudsen, L. E.; Castano, A.; Rudnai, P.; Gutleb, A.; Ligocka, D.; Lupsa, I. R.; Berglund, M.; Horvat, M.; Halzlova, K.; Schoeters, G.; Koppen, G.; Hadjipanayis, A.; Krskova, A.; Középesy, S.; Arendt, M.; Fischer, M. E.; Janasik, B.; Gurzau, A. E.; Gurzau, E. S.; Grandér, M.; Larsson, K.; Jajcaj, M.; Kolossa-Gehring, M.; Sepai, O.; Exley, K.; Bartolome, M.; Cutanda, F.; Mazej, D.; Nielsen, J. K.S.; Snoj-Tratnik, J.; Schwedler, G.; Fiddicke, U.; Seiwert, M.; Govarts, E.; Den Hond, E.; Koch, H. M.; Lopez, A.; Joas, A.; Joas, R., 2015, "Gender differences in cadmium and cotinine levels in prepubertal children [* Cross-Reference *]", https://lore.list.lu/citation?persistentId=perma:LIST.ZOUNOF, LIST Open Repository, V1

Learn about Data Citation Standards.

Contact Owner

Dataset Metrics

0 Downloads

Description	Susceptibility to environmental stressors has been described for fetal and early childhood development. However, the possible susceptibility of the prepubertal period, characterized by the orchestration of the organism towards sexual maturation and adulthood has been poorly investigated and exposure data are scarce. In the current study levels of cadmium (Cd), cotinine and creatinine in urine were analyzed in a subsample 216 children from 12 European countries within the DEMOCOPHES project. The children were divided into six age-sex groups: boys (6-8 years, 9-10 years and 11 years old), and girls (6-7 years, 8-9 years, 10-11 years). The number of subjects per group was between 23 and 53. The cut off values were set at 0.1 μg/L for Cd, and 0.8 μg/L for cotinine defined according to the highest limit of quantification. The levels of Cd and cotinine were adjusted for creatinine level. In the total subsample group, the median level of Cd was 0.180. μg/L (range 0.10-0.69 μg/L), and for cotinine the median wet weight value was 1.50 μg/L (range 0.80-39.91 μg/L). There was no significant difference in creatinine and cotinine levels between genders and age groups. There was a significant correlation between levels of cadmium and creatinine in all children of both genders. This shows that even at such low levels the possible effect of cadmium on kidney function was present and measurable. An increase in Cd levels was evident with age. Cadmium levels were significantly different between 6-7 year old girls, 11 year old boys and 10-11 year old girls. As there was a balanced distribution in the number of subjects from countries included in the study, bias due to data clustering was not probable. The impact of low Cd levels on kidney function and gender differences in Cd levels needs further investigation. (2015-01-01) *This entry has been automatically imported via Infodoc(ASO) CSV by LIST harvest scripts. Please refer to https://doi.org/10.1016/j.envres.2014.10.008 for the original and latest version of the dataset and data downloads* (2025-11-17)
Subject	Other
Keyword	early childhood development, levels, childhood development, environmental stressors, fetal and early
License/Data Use Agreement	Custom Dataset Terms


There are no files in this dataset.

Citation Metadata

Persistent Identifier	perma:LIST.ZOUNOF
Publication Date	2025-12-09
Title	Gender differences in cadmium and cotinine levels in prepubertal children [* Cross-Reference *]
Other Identifier	https://doi.org/10.1016/j.envres.2014.10.008
Author	Fucic, A. (Institut za Medicinska Istrazivanja i Medicinu Rada) Plavec, D. (Srebrnjak Children’s Hospital) Casteleyn, L. (KU Leuven) Aerts, D. (Food Chain Safety and Environment - DG Environment) Biot, P. (Multilateral and Strategic Affairs) Katsonouri, A. (Ministry of Health) Cerna, M. (Laboratoire National de Sante Luxembourg, National Institute of Public Health Prague) Knudsen, L. E. (Københavns Universitet) Castano, A. (Instituto de Salud Carlos III) Rudnai, P. (National Institute of Environmental Health Budapest) Gutleb, A. (Luxembourg Institute of Science and Technology) Ligocka, D. (Instytut Medycyny Pracy im. Prof. J. Nofera) Lupsa, I. R. (Environmental Health Center) Berglund, M. (Karolinska Institutet) Horvat, M. (Institute Josef Stefan) Halzlova, K. (Public Health Authority, Ministry of Health) Schoeters, G. (Vlaamse Instelling voor Technologisch Onderzoek) Koppen, G. (Vlaamse Instelling voor Technologisch Onderzoek) Hadjipanayis, A. (Ministry of Health) Krskova, A. (Laboratoire National de Sante Luxembourg, National Institute of Public Health Prague) Középesy, S. (National Institute of Environmental Health Budapest) Arendt, M. Fischer, M. E. (Laboratoire National de Sante Luxembourg, National Institute of Public Health Prague) Janasik, B. (Instytut Medycyny Pracy im. Prof. J. Nofera) Gurzau, A. E. (Environmental Health Center) Gurzau, E. S. (Environmental Health Center) Grandér, M. (Karolinska Institutet) Larsson, K. (Karolinska Institutet) Jajcaj, M. (Institute Josef Stefan) Kolossa-Gehring, M. (Federal Environment Agency (UBA)) Sepai, O. (Public Health England) Exley, K. (Public Health England) Bartolome, M. (Instituto de Salud Carlos III) Cutanda, F. (Instituto de Salud Carlos III) Mazej, D. (Institute Josef Stefan) Nielsen, J. K.S. (Københavns Universitet) Snoj-Tratnik, J. (Institute Josef Stefan) Schwedler, G. (Federal Environment Agency (UBA)) Fiddicke, U. (Federal Environment Agency (UBA)) Seiwert, M. (Federal Environment Agency (UBA)) Govarts, E. (Vlaamse Instelling voor Technologisch Onderzoek) Den Hond, E. (Vlaamse Instelling voor Technologisch Onderzoek) Koch, H. M. (Institut für Prävention und Arbeitsmedizin der Deutschen Gesetzlichen Unfallversicherung) Lopez, A. (Instituto de Salud Carlos III) Joas, A. (BiPRO GmbH) Joas, R. (BiPRO GmbH)
Point of Contact	Use email button above to contact. LIST RDS (LIST)
Description	Susceptibility to environmental stressors has been described for fetal and early childhood development. However, the possible susceptibility of the prepubertal period, characterized by the orchestration of the organism towards sexual maturation and adulthood has been poorly investigated and exposure data are scarce. In the current study levels of cadmium (Cd), cotinine and creatinine in urine were analyzed in a subsample 216 children from 12 European countries within the DEMOCOPHES project. The children were divided into six age-sex groups: boys (6-8 years, 9-10 years and 11 years old), and girls (6-7 years, 8-9 years, 10-11 years). The number of subjects per group was between 23 and 53. The cut off values were set at 0.1 μg/L for Cd, and 0.8 μg/L for cotinine defined according to the highest limit of quantification. The levels of Cd and cotinine were adjusted for creatinine level. In the total subsample group, the median level of Cd was 0.180. μg/L (range 0.10-0.69 μg/L), and for cotinine the median wet weight value was 1.50 μg/L (range 0.80-39.91 μg/L). There was no significant difference in creatinine and cotinine levels between genders and age groups. There was a significant correlation between levels of cadmium and creatinine in all children of both genders. This shows that even at such low levels the possible effect of cadmium on kidney function was present and measurable. An increase in Cd levels was evident with age. Cadmium levels were significantly different between 6-7 year old girls, 11 year old boys and 10-11 year old girls. As there was a balanced distribution in the number of subjects from countries included in the study, bias due to data clustering was not probable. The impact of low Cd levels on kidney function and gender differences in Cd levels needs further investigation. (2015-01-01) *This entry has been automatically imported via Infodoc(ASO) CSV by LIST harvest scripts. Please refer to https://doi.org/10.1016/j.envres.2014.10.008 for the original and latest version of the dataset and data downloads* (2025-11-17)
Subject	Other
Keyword	early childhood development levels childhood development environmental stressors fetal and early
Deposit Date	2015-01-01
Data Type	Article

Dataset Terms

License/Data Use Agreement

Our Community Norms as well as good scientific practices expect that proper credit is given via citation. Please use the data citation shown on the dataset page.

Custom Dataset Terms - the following Custom Dataset Terms have been defined for this dataset.

Please refer to the original source for terms.

Dataset Version	Summary	Contributors	Published on
No records found.

Edit File

This file has already been deleted (or replaced) in the current version. It may not be edited.

Restrict Access

Restricting limits access to published files. People who want to use the restricted files can request access by default. If you disable request access, you must add information about access to the Terms of Access field.

Learn about restricting files and dataset access in the User Guide.

Request Access

Enable access request

You must enable request access or add terms of access to restrict file access.

Terms of Access for Restricted Files

Save Changes

Edit Embargo

The selected file or files have already been published. Contact an administrator to change the embargo date or reason of the file or files.

Edit Retention Period

The selected file or files have already been published. Contact an administrator to change the retention period date or reason of the file or files.

Delete Files

The file will be deleted after you click on the Delete button.

Files will not be removed from previously published versions of the dataset.

Select File(s)

Please select one or more files.

Share Dataset

Share this dataset on your favorite social media networks.

Continue

Dataset Citations

Citations for this dataset are retrieved from Crossref via DataCite using Make Data Count standards. For more information about dataset metrics, please refer to the User Guide.

Sorry, no citations were found.

Inaccessible Files Selected

The selected file(s) may not be downloaded because you have not been granted access or the file(s) have a retention period that has expired or the files can only be transferred via Globus.

You may request access to any restricted file(s) by clicking the Request Access button.

Ineligible Files Selected

The selected file(s) may not be transferred because you have not been granted access or the file(s) have a retention period that has expired or the files are not Globus accessible.

You may request access to any restricted file(s) by clicking the Request Access button.

Download Options

The files selected are too large to download as a ZIP.

You can select individual files that are below the 100.0 MB download limit from the files table, or use the Data Access API for programmatic access to the files.

Select File(s)

Please select a file or files to be downloaded.

Inaccessible Files Selected

The selected file(s) may not be downloaded because you have not been granted access or the file(s) have a retention period that has expired.

Click Continue to download the files you have access to download.

Ineligible Files Selected

Some file(s) cannot be transferred. (They are restricted, embargoed, with an expired retention period, or not Globus accessible.)

Click Continue to transfer the elligible files.

Delete Dataset

Are you sure you want to delete this dataset and all of its files? You cannot undelete this dataset.

Delete Draft Version

Are you sure you want to delete this draft version? Files will be reverted to the most recently published version. You cannot undelete this draft.

Unpublished Dataset Preview URL

Preview URL can only be used with unpublished versions of datasets.

Unpublished Dataset Preview URL

Are you sure you want to disable the Preview URL? If you have shared the Preview URL with others they will no longer be able to use it to access your unpublished dataset.

Delete Files

The file(s) will be deleted after you click on the Delete button.

Files will not be removed from previously published versions of the dataset.

Compute

This dataset contains restricted files you may not compute on because you have not been granted access.

Deaccession Dataset

Are you sure you want to deaccession? This is permanent and the selected version(s) will no longer be viewable by the public.

Deaccession Dataset

Are you sure you want to deaccession this dataset? This is permanent an it will no longer be viewable by the public.

Version Differences Details

Please select two versions to view the differences.

Version Differences Details

Version:
Last Updated:

Select File(s)

Please select a file or files for access request.

Select File(s)

Embargoed files cannot be accessed. Please select an unembargoed file or files for your access request.

Edit Tags

Select existing file tags or create new tags to describe your files. Each file can have more than one tag.

Request Access

You need to Log In to request access.

Dataset Terms

Please confirm and/or complete the information needed below in order to request access to files in this dataset.

This dataset is made available under the following terms. Please confirm and/or complete the information needed below in order to continue.

License/Data Use Agreement

Our Community Norms as well as good scientific practices expect that proper credit is given via citation. Please use the data citation shown on the dataset page.

Custom terms specific to this dataset Custom Dataset Terms - the following Custom Dataset Terms have been defined for this dataset.

Preview Guestbook

Upon downloading files the guestbook asks for the following information.

Guestbook Name

Collected Data

Account Information

Package File Download

Use the Download URL in a Wget command or a download manager to download this package file. Download via web browser is not recommended. User Guide - Downloading a Dataverse Package via URL

Download URL

https://lore.list.lu/api/access/datafile/

Compute Batch

Clear Batch

Dataset	Persistent Identifier	Change Compute Batch

Compute Batch

Submit for Review

You will not be able to make changes to this dataset while it is in review.

Publish Dataset

Are you sure you want to republish this dataset?

Select if this is a minor or major version update.

Minor Release (1.1)

Major Release (2.0)

Publish Dataset

This dataset cannot be published until LIST Open Repository is published by its administrator.

Return to Author

Return this dataset to contributor for modification. The reason for return entered below will be sent by email to the author.

Curation Status History

Status	Date	Assigner
No records found.

Add/Edit a Version Note

Styled Citation