An in vitro coculture system for the detection of sensitization following aerosol exposure_suppl [* Cross-Reference *]

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Aline Chary, 2026, "An in vitro coculture system for the detection of sensitization following aerosol exposure_suppl [* Cross-Reference *]", https://lore.list.lu/citation?persistentId=perma:LIST.ZKFJ8Y, LIST Open Repository, V1
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Description
The aim of the study was to develop an in vitro model that mimics the alveolar-capillary barrier and that allows assessment of the respiratory sensitizing potential of substances. The 3D in vitro model cultured at the air liquid interface consists of alveolar type II epithelial cells (A549), endothelial cells (EA.hy926), macrophage-like cells (PMA-differentiated THP-1), and dendritic-like cells (non-differentiated THP-1). This alveolar model was exposed apically to nebulized chemical respiratory sensitizers (phthalic anhydride (PA) and trimellitic anhydride (TMA)) or to irritants (methyl salicylate (MeSa) and acrolein (Acr)) at concentrations inducing 25% cytotoxicity. The exposure to respiratory sensitizers induced den­dritic-like cell activation and a specific cytokine release pattern, while exposure to irritants did not. In addition, the cell surface marker OX40L was found to identify dendritic-like cell activation by high molecular weight allergens. With this in vitro model we can postulate a set of promising markers that allow the discrimination of chemical respiratory sensitizers from irritants. (2019-01-01)
***This entry has been automatically imported via OpenAlex by LIST harvest scripts. Please refer to https://doi.org/10.14573/altex.1901241s for the original and latest version of the publication*** (2026-07-01)
Subject Medicine, Health and Life Sciences
Keyword Trimellitic anhydride, Chemistry, In vitro, Acrolein, Respiratory system, A549 cell, Immunology, Sensitization, Molecular biology, Biochemistry, Biology, Anatomy, Organic chemistry
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