Patient-reported outcomes in patients with hematologic malignancies treated with CAR T-cell therapy in Europe [* Cross-Reference *]

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Elise R. A. Pennings; Anne M. Spanjaart; Frederick W. Thielen; Simone Oerlemans; Anna Fleischer; Carmen Sanges; María Gomes da Silva; Yolanda Cabrerizo; Pacôme Lecot; Lutgart Roux-Opstaele; Caroline Dreuillet; Eglys González‐Marcano; Olga Millán; Ulrich Jäger; Julio Delgado; Maik Luu; Barbara Huber; Margot Lorrain; Mariana Pina; Andreas Kremer; Natacha Bolaños; Solène Clavreul; Samantha Nier; R. D. Liu; Birgit I. Lissenberg‐Witte; Sébastien Anguille; Marie Robin; Emma Morris; Anna Sureda; Marie Préau; Myriam Pannard; Geertruida H. de Bock; Scott Wagers; Hélène Trebeden‐Negre; Delphine Maucort‐Boulch; Michael Hudecek; Carin A. Uyl‐de Groot; Marie José Kersten, 2026, "Patient-reported outcomes in patients with hematologic malignancies treated with CAR T-cell therapy in Europe [* Cross-Reference *]", https://lore.list.lu/citation?persistentId=perma:LIST.W2OCQV, LIST Open Repository, V1
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Patient-reported outcomes (PROs) give direct insights into the treatment's impact on patient's life and complement clinical outcomes. However, since the advent of chimeric antigen receptor T-cell therapy (CAR-T), PROs have been underreported. Particularly, little is known about long-term health-related quality of life (HRQoL) and dimensions such as mental- and social well-being, working life, and financial burden. Therefore, we evaluated multidimensional PROs in a cross-sectional study among European patients who received CAR-T for hematologic malignancies. Patients completed validated questionnaires (EQ-5D-5L/EORTC-QLQ-C30/PCL-5/modified-iPCQ) and ad hoc items on treatment experiences, unmet care needs, and HRQoL. The survey was available online (January–October 2023) in 7 languages. Outcomes were compared with the European general population, a matched CAR-T–naive cohort with hematologic malignancies and across subgroups, using established thresholds for clinically important differences/problems and regression models. From 10 European countries, 389 patients participated (>1 year post-CAR-T: 56%). Mean EQ-VAS was 73.1 (standard deviation, 18.5). HRQoL was similar or better than reference cohorts, except for role-, social-, and cognitive-functioning. Physical-functioning problems were most frequently reported (41%), particularly by women, older individuals, and those who experienced neurotoxicity. The latter subgroup also reported more cognitive- and social-functioning problems. Anxiety regarding disease recurrence (76%), infections (66%) and long-term side effects (59%) was common. Among working-age patients, 72% could continue paid work after CAR-T. Younger patients (32%) reported more financial difficulties than older patients (9%). This study shows favorable general HRQoL after CAR-T compared with reference cohorts. However, a notable proportion of patients experienced problems in physical-, mental- and social well-being. We identified high-risk subgroups and care needs that should be addressed during follow-up. (2025-09-24)
***This entry has been automatically imported via OpenAlex by LIST harvest scripts. Please refer to https://doi.org/10.1182/bloodadvances.2025017081 for the original and latest version of the publication*** (2026-07-01)
Subject Medicine, Health and Life Sciences
Keyword Quality of life (healthcare), Cohort, Anxiety, Disease, Cohort study, MEDLINE, Depression (economics)
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