Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis [* Cross-Reference *]

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Muhua Yu; Hongjie Dai; Xiaocui Zhong; Qibin Li; Hui Yuan; Y S Yang; Daiyong Huang; Li Zhang; Rui Ran; He Tian; Yuanzhi Huang; Silas Villas‐Boas; Sergey Tumanov; Richard D. Cannon; Boris Novakovic; Richard Saffery; Y S Zhang; Xiaojing Dong; Ting­-Li Han, 2026, "Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis [* Cross-Reference *]", https://lore.list.lu/citation?persistentId=perma:LIST.V21S0I, LIST Open Repository, V1
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Description
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific disorder characterized by elevated maternal serum total bile acid (TBA) and increased risk of adverse fetal outcomes, yet current therapies and preventive strategies remain suboptimal. Here, we present a preclinical investigation of nanocellulose as a gut microbiota-targeted dietary intervention to restore bile acid homeostasis. We demonstrate that nanocellulose, particularly cellulose nanofibers (CNF), administered prophylactically, attenuated maternal TBA and improved offspring survival in a rat ICP model by enriching probiotic microbial taxa while suppressing bile acid-transforming bacteria. These microbial shifts promoted the accumulation of fecal primary bile acids and activation of gut-liver farnesoid X receptor (FXR) signaling. This cascade reduced intestinal reabsorption and hepatic synthesis of bile acids while promoting their excretion in feces. Collectively, pre-gestational CNF effectively lowered systemic bile acid burden and mitigated the ICP phenotype. Our findings identify CNF as a biosafe, microbiota-responsive dietary fiber with translational potential for early preventive management of bile acid-related disorders during pregnancy. (2026-06-09)
***This entry has been automatically imported via OpenAlex by LIST harvest scripts. Please refer to https://doi.org/10.1002/advs.202518337 for the original and latest version of the publication*** (2026-07-01)
Subject Chemistry; Medicine, Health and Life Sciences
Keyword Bile acid, Nanocellulose, Farnesoid X receptor, Cholestasis, Cholestasis of pregnancy, Pregnancy, Gut flora, Reabsorption
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