Host and microbiome lipid metabolism in colorectal cancer development and therapy [* Cross-Reference *]

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Gabriel Medina Evora; Madita Brauer; Elisabeth Letellier, 2026, "Host and microbiome lipid metabolism in colorectal cancer development and therapy [* Cross-Reference *]", https://lore.list.lu/citation?persistentId=perma:LIST.SN4MQF, LIST Open Repository, V1
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Description
Colorectal cancer (CRC) remains one of the most prevalent cancers, with treatment largely dependent on surgery and chemotherapy, underscoring the need for novel or adjunct therapies. Cancer cells reprogram their lipid metabolism to support proliferation, invasiveness, and chemoresistance, making it a promising therapeutic target. Although several inhibitors of lipogenesis, lipases, lipid uptake, and lipid storage are under investigation in CRC, none have yet shown sufficient efficacy. Importantly, the tumor microenvironment (TME) and the microbiome influence CRC lipid metabolism by supplying compensatory lipids and engaging in crosstalk that affects the efficacy of lipid-targeting therapies. This review describes the role of lipids in CRC and explores how the TME and the gut/tumor microbiome may contribute to current challenges in the development of effective lipid-targeting therapies. (2025-09-11)
***This entry has been automatically imported via OpenAlex by LIST harvest scripts. Please refer to https://doi.org/10.1016/j.trecan.2025.08.005 for the original and latest version of the publication*** (2026-07-01)
Subject Chemistry; Medicine, Health and Life Sciences
Keyword Lipid metabolism, Microbiome, Colorectal cancer, Crosstalk, Tumor microenvironment, Cancer, Gut microbiome, Lipid A
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