Advanced in Vitro and ecotoxicological models for Graphene Oxide risk assessment: Insights from POTENTIAL [* Cross-Reference *]

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Chary, Aline; Houin, Marianne; De Luigi, Ada; Mehennaoui, Kahina; Natale, Carmina; Bigini, Paolo; Serchi, Tommaso; Diomede, Luisa, 2026, "Advanced in Vitro and ecotoxicological models for Graphene Oxide risk assessment: Insights from POTENTIAL [* Cross-Reference *]", https://lore.list.lu/citation?persistentId=perma:LIST.OOASVA, LIST Open Repository, V1
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Within the POTENTIAL project, this work presents a tiered strategy combining human in vitro models and ecotoxicological assays to assess graphene oxide (GO) safety. Submerged monocultures (A549 and Caco-2) and the advanced ALIsens® 3D alveolar co-culture model were employed alongside Daphnia magna and Caenorhabditis elegans assays. ATP measurement emerged as a robust viability endpoint in monocultures, while the ALIsens® model provided insight into immune and inflammatory responses. Ecotoxicological testing revealed sublethal behavioral effects despite limited acute toxicity at guideline concentrations. The integrated approach delivers reproducible, human- and environmentally relevant data to support regulatory decision-making and safe commercialization of advanced nanomaterials. (2026-02-17)
***This entry has been automatically imported via Datacite by LIST harvest scripts. Please refer to https://doi.org/10.5281/zenodo.18673283 for the original and latest version of the dataset and data downloads*** (2026-02-18)
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