When metabolism meets physiology: Harvey and Harvetta [* Cross-Reference *]

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Ines Thiele; Swagatika Sahoo; Almut Heinken; Laurent Heirendt; Maike K. Aurich; Alberto Noronha; Ronan M. T. Fleming, 2026, "When metabolism meets physiology: Harvey and Harvetta [* Cross-Reference *]", https://lore.list.lu/citation?persistentId=perma:LIST.MUANVV, LIST Open Repository, V1

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Description	Abstract Precision medicine is an emerging paradigm that requires realistic, mechanistic models capturing the complexity of the human body. We present two comprehensive molecular to physiological-level, gender-specific whole-body metabolism (WBM) reconstructions, named Harvey, in recognition of William Harvey, and Harvetta. These validated, knowledge-based WBM reconstructions capture the metabolism of 20 organs, six sex organs, six blood cells, the gastrointestinal lumen, systemic blood circulation, and the blood-brain barrier. They represent 99% of the human body weight, when excluding the weight of the skeleton. Harvey and Harvetta can be parameterized based on physiological, dietary, and omics data. They correctly predict inter-organ metabolic cycles, basal metabolic rates, and energy use. We demonstrate the integration of microbiome data thereby allowing the assessment of individual-specific, organ-level modulation of host metabolism by the gut microbiota. The WBM reconstructions and the individual organ reconstructions are available under http://vmh.life . Harvey and Harvetta represent a pivotal step towards virtual physiological humans. (2018-01-29) *This entry has been automatically imported via OpenAlex by LIST harvest scripts. Please refer to https://doi.org/10.1101/255885 for the original and latest version of the publication* (2026-07-01)
Subject	Chemistry; Medicine, Health and Life Sciences
Keyword	Gut microbiome, Biology, Physiology, Organ system, Energy metabolism, Microbiome, Metabolism, Basal metabolic rate, Computational biology, Bioinformatics, Medicine, Internal medicine, Endocrinology, Disease
License/Data Use Agreement	Custom Dataset Terms


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Persistent Identifier	perma:LIST.MUANVV
Publication Date	2026-07-06
Title	When metabolism meets physiology: Harvey and Harvetta [* Cross-Reference *]
Other Identifier	https://doi.org/10.1101/255885 OpenAlex ID: https://openalex.org/W2792790130
Author	Ines Thiele (University of Luxembourg, Luxembourg Institute of Science and Technology) - ORCID: https://orcid.org/0000-0002-8071-7110 Swagatika Sahoo (University of Luxembourg) - ORCID: https://orcid.org/0000-0003-3773-8597 Almut Heinken (University of Luxembourg) - ORCID: https://orcid.org/0000-0001-6938-8072 Laurent Heirendt (University of Luxembourg) - ORCID: https://orcid.org/0000-0003-1861-0037 Maike K. Aurich (University of Luxembourg) Alberto Noronha (University of Luxembourg) - ORCID: https://orcid.org/0000-0002-0935-4599 Ronan M. T. Fleming (University of Luxembourg) - ORCID: https://orcid.org/0000-0001-5346-9812
Point of Contact	Use email button above to contact. LIST QDKM (LIST)
Description	Abstract Precision medicine is an emerging paradigm that requires realistic, mechanistic models capturing the complexity of the human body. We present two comprehensive molecular to physiological-level, gender-specific whole-body metabolism (WBM) reconstructions, named Harvey, in recognition of William Harvey, and Harvetta. These validated, knowledge-based WBM reconstructions capture the metabolism of 20 organs, six sex organs, six blood cells, the gastrointestinal lumen, systemic blood circulation, and the blood-brain barrier. They represent 99% of the human body weight, when excluding the weight of the skeleton. Harvey and Harvetta can be parameterized based on physiological, dietary, and omics data. They correctly predict inter-organ metabolic cycles, basal metabolic rates, and energy use. We demonstrate the integration of microbiome data thereby allowing the assessment of individual-specific, organ-level modulation of host metabolism by the gut microbiota. The WBM reconstructions and the individual organ reconstructions are available under http://vmh.life . Harvey and Harvetta represent a pivotal step towards virtual physiological humans. (2018-01-29) *This entry has been automatically imported via OpenAlex by LIST harvest scripts. Please refer to https://doi.org/10.1101/255885 for the original and latest version of the publication* (2026-07-01)
Subject	Chemistry; Medicine, Health and Life Sciences
Keyword	Gut microbiome Biology Physiology Organ system Energy metabolism Microbiome Metabolism Basal metabolic rate Computational biology Bioinformatics Medicine Internal medicine Endocrinology Disease
Topic Classification	Diet and metabolism studies Adipose Tissue and Metabolism Metabolomics and Mass Spectrometry Studies
Deposit Date	2018-01-29
Data Type	Preprint
Data Source	bioRxiv (Cold Spring Harbor Laboratory)

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