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Persistent Identifier
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perma:LIST.MIQMBJ |
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Publication Date
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2026-07-06 |
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Title
| Multi-omic network inference from time-series data [* Cross-Reference *] |
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Other Identifier
| https://doi.org/10.1038/s41540-025-00591-1
OpenAlex ID: https://openalex.org/W4415155692 |
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Author
| María Moscardó Garcia (University of Luxembourg) - ORCID: https://orcid.org/0000-0001-9352-4097
Atte Aalto (University of Luxembourg) - ORCID: https://orcid.org/0000-0002-6876-474X
Arthur N. Montanari (Northwestern University, University of Luxembourg) - ORCID: https://orcid.org/0000-0002-4866-3888
Alexander Skupin (University of Luxembourg, University of California San Diego, Luxembourg Institute of Science and Technology) - ORCID: https://orcid.org/0000-0002-8955-8304
Jorge Gonçalves (University of Luxembourg, University of Cambridge) - ORCID: https://orcid.org/0000-0002-0117-0322 |
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Point of Contact
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Use email button above to contact.
LIST QDKM (LIST) |
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Description
| Biological phenotypes emerge from complex interactions across molecular layers. Yet, data-driven approaches to infer these regulatory networks have primarily focused on single-omic studies, overlooking inter-layer regulatory relationships. To address these limitations, we developed MINIE, a computational method that integrates multi-omic data from bulk metabolomics and single-cell transcriptomics through a Bayesian regression approach that explicitly models the timescale separation between molecular layers. We validate the method on both simulated datasets and experimental Parkinson’s disease data. MINIE exhibits accurate and robust predictive performance across and within omic layers, including curated multi-omic networks and the lac operon. Benchmarking demonstrated significant improvements over state-of-the-art methods while ranking among the top performers in comprehensive single-cell network inference analysis. The integration of regulatory dynamics across molecular layers and temporal scales provides a powerful tool for comprehensive multi-omic network inference. (2025-10-14)
***This entry has been automatically imported via OpenAlex by LIST harvest scripts. Please refer to https://doi.org/10.1038/s41540-025-00591-1 for the original and latest version of the publication*** (2026-07-01) |
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Subject
| Chemistry; Medicine, Health and Life Sciences |
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Keyword
| Inference
Benchmarking
Bayesian network
Ranking (information retrieval)
Gene regulatory network
Dynamic Bayesian network
Bayesian probability
Bayesian inference
Data integration |
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Topic Classification
| Bioinformatics and Genomic Networks
Gene Regulatory Network Analysis
Microbial Metabolic Engineering and Bioproduction |
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Deposit Date
| 2025-10-14 |
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Data Type
| Article |
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Data Source
| npj Systems Biology and Applications |
