MACRAMÉ Deliverable Report D2.1: Report on the MACRAMÉ Control Material Library - first annual report [* Cross-Reference *]

Version 1.0
Caputo, Fanny; Favre, Georges; Delcour, Simon; Wiemann, Martin; Serchi, Tommaso; Meyer-Plath, Asmus Andres; Günday-Türeli, Nazende; Weltring, Klaus-Michael; Gupta, Govind; Wick, Peter; Buerki-Thurnherr, Tina; Friedrichs, Steffi, 2025, "MACRAMÉ Deliverable Report D2.1: Report on the MACRAMÉ Control Material Library - first annual report [* Cross-Reference *]", https://lore.list.lu/citation?persistentId=perma:LIST.MACTYV, LIST Open Repository, V1
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Setting up the Control Material Library (CML) is the objective of the MACRAMÉ Project’s Task 2.1. The library contains representative materials with largely known properties impacting the in vitro test development and of materials to be investigated in the use cases (UCs). Data gaps will be filled, and measurement protocols will be developed to identify and describe critical attributes impacting the toxicological profiles of CML materials, which fall into three main categories: i. Materials of known properties to develop, harmonise and validate the generation of aerosols and the development of toxicological in vitro models; ii. Advanced Materials (AdMas) in their pristine status (e.g. Few Layer Graphene-FLG, Graphene Oxide-GO, Carbon Nanotubes-CNTs, poly(lactic-co-glycolic acid)-PLGA nanoparticles and Polycaprolactone-PCL nanoparticles), representing materials and products investigated in MACRAMÉ’s use cases; iii. Materials to study the properties of UC products at their “end of life”, i.e. after controlled abrasion or incineration. The aim of setting up a specially tailored CML is many-fold; the selected materials shall be used for the development, harmonisation and standardisation of the methods included in all MACRAMÉ’s R&I activities. Besides the controlled aerosol generation and the harmonisation of the tiered in-vitro model approach for a toxicological risk assessment, materials for establishing high-resolution imaging methods were to be included, allowing a quantification and characterisation of nanomaterials and AdMas in complex matrices. Eventually, a well selected sub-group of CML materials shall be made available for the scientific community to support studies on safety and characterisation of AdMas beyond the duration of the MACRAMÉ Project. In the first seven months of the Project, all the partners involved in WP2, in collaboration with WP1 and WP4 have taken the following measures: a.    selected the materials to be included in the CML, b.    identified a list of the critical properties to be characterised, and c.     included the different materials to the R&I strategy, identifying the most appropriate candidates for the development, optimisation and harmonisation of the methods included in Task 2.2 - generation and characterisation of controlled aerosols, Task 2.3 - Improvement, benchmarking and validation of in vitro / ex vivo models for inhalation toxicology of AdMas, and Task 2.4 - Development of high-resolution imaging methods for the quantification of AdMas in cells and tissues. Those progress steps are described below in the first annual report (D2.1). (2025-04-02)
***This entry has been automatically imported via Datacite by LIST harvest scripts. Please refer to https://doi.org/10.5281/zenodo.15125882 for the original and latest version of the dataset and data downloads*** (2025-04-06)
Subject Physics
Keyword CML materials
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