Time Patterns in Internal Human Exposure Data to Bisphenols, Phthalates, DINCH, Organophosphate Flame Retardants, Cadmium and Polyaromatic Hydrocarbons in Europe [* Cross-Reference *]

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Rodriguez Martin, Laura; Gilles, Liese; Helte, Emilie; Åkesson, Agneta; Tägt, Jonas; Covaci, Adrian; Sakhi, Amrit K.; Van Nieuwenhuyse, An; Katsonouri, Andromachi; Andersson, Anna Maria; Gutleb, Arno C.; Janasik, Beata; Appenzeller, Brice; Gabriel, Catherine; Thomsen, Cathrine; Mazej, Darja; Sarigiannis, Denis; Anastasi, Elena; Barbone, Fabio; Tolonen, Hanna; Frederiksen, Hanne; Klanova, Jana; Koponen, Jani; Tratnik, Janja Snoj; Pack, Kim; Gudrun, Koppen; Ólafsdóttir, Kristin; Knudsen, Lisbeth E.; Rambaud, Loïc; Strumylaite, Loreta; Murinova, Lubica Palkovicova; Fabelova, Lucia; Riou, Margaux; Berglund, Marika; Szabados, Maté; Imboden, Medea; Laeremans, Michelle; Eštóková, Milada; Janev Holcer, Natasa; Probst-Hensch, Nicole; Vodrazkova, Nicole; Vogel, Nina; Piler, Pavel; Schmidt, Phillipp; Lange, Rosa; Namorado, Sónia; Kozepesy, Szilvia; Szigeti, Tamás; Halldorsson, Thorhallur I.; Weber, Till; Jensen, Tina Kold; Rosolen, Valentina; Puklova, Vladimira; Wasowicz, Wojciech; Sepai, Ovnair; Stewart, Lorraine; Kolossa-Gehring, Marike; Esteban-López, Marta; Castaño, Argelia; Bessems, Jos; Schoeters, Greet; Govarts, Eva, 2023, "Time Patterns in Internal Human Exposure Data to Bisphenols, Phthalates, DINCH, Organophosphate Flame Retardants, Cadmium and Polyaromatic Hydrocarbons in Europe [* Cross-Reference *]", https://lore.list.lu/citation?persistentId=perma:LIST.JZHNLA, LIST Open Repository, V1
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Human biomonitoring (HBM) data in Europe are often fragmented and collected in different EU countries and sampling periods. Exposure levels for children and adult women in Europe were evaluated over time. For the period 2000–2010, literature and aggregated data were collected in a harmonized way across studies. Between 2011–2012, biobanked samples from the DEMOCOPHES project were used. For 2014–2021, HBM data were generated within the HBM4EU Aligned Studies. Time patterns on internal exposure were evaluated visually and statistically using the 50th and 90th percentiles (P50/P90) for phthalates/DINCH and organophosphorus flame retardants (OPFRs) in children (5–12 years), and cadmium, bisphenols and polycyclic aromatic hydrocarbons (PAHs) in women (24–52 years). Restricted phthalate metabolites show decreasing patterns for children. Phthalate substitute, DINCH, shows a non-significant increasing pattern. For OPFRs, no trends were statistically significant. For women, BPA shows a clear decreasing pattern, while substitutes BPF and BPS show an increasing pattern coinciding with the BPA restrictions introduced. No clear patterns are observed for PAHs or cadmium. Although the causal relations were not studied as such, exposure levels to chemicals restricted at EU level visually decreased, while the levels for some of their substitutes increased. The results support policy efficacy monitoring and the policy-supportive role played by HBM. (2023-12-04)
***This entry has been automatically imported via Infodoc(ASO) CSV by LIST harvest scripts. Please refer to https://doi.org/10.3390/toxics11100819 for the original and latest version of the dataset and data downloads*** (2025-09-03)
Subject Earth and Environmental Sciences
Keyword bisphenols, cadmium, DINCH, hazardous chemical, human biomonitoring, OPFRs, PAHs, phthalates
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