Birth mode is associated with earliest strain-conferred gut microbiome functions and immunostimulatory potential [* Cross-Reference *]

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Linda Wampach; Anna Heintz‐Buschart; Joëlle V. Fritz; Javier Ramiro‐Garcia; Janine Habier; Malte Herold; Shaman Narayanasamy; Anne Kaysen; Angela Hogan; L. Bindl; Jean Bottu; Rashi Halder; Conny Sjöqvist; Patrick May; Anders F. Andersson; Carine de Beaufort; Paul Wilmes, 2026, "Birth mode is associated with earliest strain-conferred gut microbiome functions and immunostimulatory potential [* Cross-Reference *]", https://lore.list.lu/citation?persistentId=perma:LIST.JDHUJT, LIST Open Repository, V1
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Description
The rate of caesarean section delivery (CSD) is increasing worldwide. It remains unclear whether disruption of mother-to-neonate transmission of microbiota through CSD occurs and whether it affects human physiology. Here we perform metagenomic analysis of earliest gut microbial community structures and functions. We identify differences in encoded functions between microbiomes of vaginally delivered (VD) and CSD neonates. Several functional pathways are over-represented in VD neonates, including lipopolysaccharide (LPS) biosynthesis. We link these enriched functions to individual-specific strains, which are transmitted from mothers to neonates in case of VD. The stimulation of primary human immune cells with LPS isolated from early stool samples of VD neonates results in higher levels of tumour necrosis factor (TNF-α) and interleukin 18 (IL-18). Accordingly, the observed levels of TNF-α and IL-18 in neonatal blood plasma are higher after VD. Taken together, our results support that CSD disrupts mother-to-neonate transmission of specific microbial strains, linked functional repertoires and immune-stimulatory potential during a critical window for neonatal immune system priming. (2018-11-26)
***This entry has been automatically imported via OpenAlex by LIST harvest scripts. Please refer to https://doi.org/10.1038/s41467-018-07631-x for the original and latest version of the publication*** (2026-07-01)
Subject Medicine, Health and Life Sciences
Keyword Immune system, Microbiome, Lipopolysaccharide, Biology, Metagenomics, Immunology, Tumor necrosis factor alpha, Gut flora, Priming (agriculture), Transmission (telecommunications), Microbiology, Physiology, Bioinformatics, Genetics, Gene
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