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Persistent Identifier
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perma:LIST.IACEFM |
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Publication Date
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2026-07-06 |
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Title
| Mechanics of knee meniscus results from precise balance between material microstructure and synovial fluid viscosity [* Cross-Reference *] |
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Other Identifier
| https://doi.org/10.1371/journal.pone.0304440
OpenAlex ID: https://openalex.org/W4414116695 |
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Author
| Camilo Andrés Suarez Afanador (Centre National de la Recherche Scientifique, University of Luxembourg, Luxembourg Institute of Science and Technology, Centrale Marseille, Luxembourg Institute of Socio-Economic Research)
Stéphane Urcun (University of Luxembourg, University of Utah, Luxembourg Institute of Science and Technology, Luxembourg Institute of Socio-Economic Research) - ORCID: https://orcid.org/0000-0002-5164-5904
Ivo F. Sbalzarini (Center for Systems Biology Dresden, Max Planck Institute of Molecular Cell Biology and Genetics, Physics of Life, Technische Universität Dresden) - ORCID: https://orcid.org/0000-0003-4414-4340
Stéphane Bordas (University of Luxembourg, Luxembourg Institute of Science and Technology, Luxembourg Institute of Socio-Economic Research) - ORCID: https://orcid.org/0000-0001-7622-2193
Olga Barrera (Oxford Brookes University, University of Oxford, Science Oxford) - ORCID: https://orcid.org/0000-0002-0077-9582
Mohammad Mahdi Rajabi (University of Luxembourg, Luxembourg Institute of Science and Technology, Luxembourg Institute of Socio-Economic Research) - ORCID: https://orcid.org/0000-0002-2181-6637
Romain Seil (Centre Hospitalier de Luxembourg, Luxembourg Institute of Health) - ORCID: https://orcid.org/0000-0001-8806-9384
Anas Obeidat (University of Luxembourg, Luxembourg Institute of Science and Technology, Luxembourg Institute of Socio-Economic Research) - ORCID: https://orcid.org/0000-0002-4580-1640 |
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Point of Contact
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Use email button above to contact.
LIST QDKM (LIST) |
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Description
| The meniscus plays a crucial role in the biomechanics of the knee, serving as load transmitter and reducing friction between joints. Understanding the biomechanics of the meniscus is essential to effective treatment of knee injuries and degenerative conditions. This study aims to elucidate the relationship between the porous microstructure of the human knee meniscus and its biomechanical function, specifically focusing on fluid dynamics at the pore scale. Here, we use two central-meniscus samples extracted from a human knee and reconstruct high-resolution geometry models from μ-CT scans. By eroding the channels of the original meniscus geometry, we simulate perturbed microstructures with varying porosities (53% to 80%), whilst preserving the connectivity of the porous structure. We numerically solve for the fluid dynamics in the meniscus using a mesh-free particle method, considering various inlet pressure conditions, characterising the fluid flow within the microstructures. The results of the original microstructure associated with a physiological dynamic viscosity of synovial fluid are in accordance with biophysical experiments on menisci. Furthermore, the eroded microstructure with a 33% increase in porosity exhibited a remarkable 120% increase in flow velocity. This emphasises the sensitivity of meniscus physiology to the porous microstructure, showing that detailed computational models can explore physiological and pathological conditions, advancing further knee biomechanics research. (2025-09-11)
***This entry has been automatically imported via OpenAlex by LIST harvest scripts. Please refer to https://doi.org/10.1371/journal.pone.0304440 for the original and latest version of the publication*** (2026-07-01) |
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Subject
| Medicine, Health and Life Sciences; Physics |
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Keyword
| Meniscus
Microstructure
Biomechanics
Synovial fluid
Porosity
Fluid dynamics
Viscosity
Rheology |
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Topic Classification
| Surface Modification and Superhydrophobicity
Blood properties and coagulation
Polymer Surface Interaction Studies |
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Deposit Date
| 2025-09-11 |
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Data Type
| Article |
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Data Source
| PLoS ONE |
