EPILEPTOGENESIS INHIBITS THE CIRCADIAN CLOCK AND RESHAPES THE DIURNAL TRANSCRIPTOMIC RHYTHMICITY IN THE MOUSE HIPPOCAMPUS [* Cross-Reference *]

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Radharani Benvenutti; Danielle do Carmo Ferreira Bruno; Matheus Gallas‐Lopes; Morten T. Venø; Estela M. Bruxel; Tammy Strickland; Arielle Ramsook; Aditi Wadgaonkar; Yiyue Jiang; Amaya Sanz‐Rodriguez; Lasse Sinkkonen; Marina K. M. Alvim; Clarissa Lin Yasuda; Fábio Rogério; Fernando Cendes; David C. Henshall; Annie M. Curtis; Katja Kobow; Íscia Lopes‐Cendes; Cristina R. Reschke, 2024, "EPILEPTOGENESIS INHIBITS THE CIRCADIAN CLOCK AND RESHAPES THE DIURNAL TRANSCRIPTOMIC RHYTHMICITY IN THE MOUSE HIPPOCAMPUS [* Cross-Reference *]", https://lore.list.lu/citation?persistentId=perma:LIST.EPIH9F, LIST Open Repository, V1
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ABSTRACT Epileptogenesis is the process that leads the brain into epileptic activity. Clinical evidence shows that ∼90% of people with epilepsy present rhythmicity in the timing of their seizures presentation. However, whether the circadian clock is a key player during epileptogenesis remains unknown. Here, we triggered epileptogenesis in mice by the intra-amygdala injection of kainic acid and profiled by RNA sequencing their hippocampal diurnal mRNA rhythmicity. We show that epileptogenesis largely reshapes the hippocampal transcriptomic rhythmicity and that the molecular clock machinery is inhibited due to the disruption of the core clock gene Bmal1 . We identified relevant dysregulated pathways and their dynamics in epileptogenesis, predicting a key role for microglial-driven neuroinflammation. We predicted the genes that Bmal1 is directly controlling over time. Finally, we sought for translational relevance evidence by performing RNA sequencing in hippocampal samples resected from patients with mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE-HS) and cross-analyzing datasets. (2024-07-04)
***This entry has been automatically imported via OpenAlex by LIST harvest scripts. Please refer to https://doi.org/10.1101/2024.07.02.601732 for the original and latest version of the publication*** (2026-07-01)
Subject Medicine, Health and Life Sciences
Keyword Epileptogenesis, Circadian rhythm, Circadian clock, Hippocampus, Neuroscience, Transcriptome, Biology, Gene, Gene expression, Genetics
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