Inflammation related responses of intestinal cells to plum and cabbage digesta with differential carotenoid and polyphenol profiles following simulated gastrointestinal digestion [* Cross-Reference *]

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Kaulmann, Anouk; Legay, Sylvain; Schneider, Yves Jacques; Hoffmann, Lucien; Bohn, Torsten, 2016, "Inflammation related responses of intestinal cells to plum and cabbage digesta with differential carotenoid and polyphenol profiles following simulated gastrointestinal digestion [* Cross-Reference *]", https://lore.list.lu/citation?persistentId=perma:LIST.DQQXTF, LIST Open Repository, V1

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Description	Scope: Plums/cabbages represent fruits/vegetables rich in carotenoids and polyphenols, and have been associated with anti-inflammatory properties. Methods and results: We tested four plum (Italian Plum, Plum 620, Ersinger, and Cherry Plum) and cabbage varieties (Duchy, Kalorama, Kale, Scots Kale) with contrasting carotenoid/polyphenol content for their capability to alter inflammation/oxidative stress following simulated gastrointestinal digestion. Digesta were exposed to Caco-2(TC-7) and to a triple-culture(Caco-2/HT-29-MTX (90:10 v/v) including THP-1 like macrophages), stimulated to induce inflammation (10 μg/mL LPS, 100 ng/mL TNF-α, 25 ng/mL IL-1-β for 24 h, the last 18 h with digesta). Endpoints investigated included IL-6, IL-8, PGE-2, NO (all ELISA), NF-κB, MAPK, IL-6, IL-8, iNOS, Nrf2, COX-2 (real-time-PCR) and Nrf2 (immunostaining). IL-6 secretion was reduced in THP-1 cells by Scots Kale and Kalorama (up to 22%, p<0.05), and IL-8 secretion in the coculture (up to 35% in plums, p<0.05). This was accompanied by decreased NF-kB expressions in THP-1 cells (up to 30%, p<0.05). Nrf2 translocation to the nucleus was partly reduced by plums and cabbages (up to 40% (p<0.05). Conclusions: Some varieties, especially in the triple-culture, reduced inflammation, though this was unrelated to concentrations of carotenoids/polyphenols. The potential of phytochemical-rich fruits and vegetables to ameliorate gastrointestinal inflammation should be further investigated. (2016-01-01) *This entry has been automatically imported via Infodoc(ASO) CSV by LIST harvest scripts. Please refer to https://doi.org/10.1002/mnfr.201500947 for the original and latest version of the dataset and data downloads* (2025-11-18)
Subject	Other
Keyword	Digestion, Epithelium, Inflammation models, Nuclear receptors and cytokines, Phytochemicals
License/Data Use Agreement	Custom Dataset Terms


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Persistent Identifier	perma:LIST.DQQXTF
Publication Date	2025-12-09
Title	Inflammation related responses of intestinal cells to plum and cabbage digesta with differential carotenoid and polyphenol profiles following simulated gastrointestinal digestion [* Cross-Reference *]
Other Identifier	https://doi.org/10.1002/mnfr.201500947
Author	Kaulmann, Anouk (Luxembourg Institute of Science and Technology) Legay, Sylvain (Luxembourg Institute of Science and Technology) Schneider, Yves Jacques (Université Catholique de Louvain) Hoffmann, Lucien (Luxembourg Institute of Science and Technology) Bohn, Torsten (Luxembourg Institute of Science and Technology, Luxembourg Institute of Health)
Point of Contact	Use email button above to contact. LIST RDS (LIST)
Description	Scope: Plums/cabbages represent fruits/vegetables rich in carotenoids and polyphenols, and have been associated with anti-inflammatory properties. Methods and results: We tested four plum (Italian Plum, Plum 620, Ersinger, and Cherry Plum) and cabbage varieties (Duchy, Kalorama, Kale, Scots Kale) with contrasting carotenoid/polyphenol content for their capability to alter inflammation/oxidative stress following simulated gastrointestinal digestion. Digesta were exposed to Caco-2(TC-7) and to a triple-culture(Caco-2/HT-29-MTX (90:10 v/v) including THP-1 like macrophages), stimulated to induce inflammation (10 μg/mL LPS, 100 ng/mL TNF-α, 25 ng/mL IL-1-β for 24 h, the last 18 h with digesta). Endpoints investigated included IL-6, IL-8, PGE-2, NO (all ELISA), NF-κB, MAPK, IL-6, IL-8, iNOS, Nrf2, COX-2 (real-time-PCR) and Nrf2 (immunostaining). IL-6 secretion was reduced in THP-1 cells by Scots Kale and Kalorama (up to 22%, p<0.05), and IL-8 secretion in the coculture (up to 35% in plums, p<0.05). This was accompanied by decreased NF-kB expressions in THP-1 cells (up to 30%, p<0.05). Nrf2 translocation to the nucleus was partly reduced by plums and cabbages (up to 40% (p<0.05). Conclusions: Some varieties, especially in the triple-culture, reduced inflammation, though this was unrelated to concentrations of carotenoids/polyphenols. The potential of phytochemical-rich fruits and vegetables to ameliorate gastrointestinal inflammation should be further investigated. (2016-01-01) *This entry has been automatically imported via Infodoc(ASO) CSV by LIST harvest scripts. Please refer to https://doi.org/10.1002/mnfr.201500947 for the original and latest version of the dataset and data downloads* (2025-11-18)
Subject	Other
Keyword	Digestion Epithelium Inflammation models Nuclear receptors and cytokines Phytochemicals
Deposit Date	2016-01-01
Data Type	Article
Data Source	Molecular Nutrition and Food Research

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