First steps toward harmonized human biomonitoring in Europe: Demonstration project to perform human biomonitoring on a European scale [* Cross-Reference *]

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Den Hond, Elly; Govarts, Eva; Willems, Hanny; Smolders, Roel; Casteleyn, Ludwine; Kolossa-Gehring, Marike; Schwedler, Gerda; Seiwert, Margarete; Fiddicke, Ulrike; Castaño, Argelia; Esteban, Marta; Angerer, Jürgen; Koch, Holger M.; Schindler, Birgit K.; Sepai, Ovnair; Exley, Karen; Bloemen, Louis; Horvat, Milena; Knudsen, Lisbeth E.; Joas, Anke; Joas, Reinhard; Biot, Pierre; Aerts, Dominique; Koppen, Gudrun; Katsonouri, Andromachi; Hadjipanayis, Adamos; Krskova, Andrea; Maly, Marek; Mørck, Thit A.; Rudnai, Peter; Kozepesy, Szilvia; Mulcahy, Maurice; Mannion, Rory; Gutleb, Arno C.; Fischer, Marc E.; Ligocka, Danuta; Jakubowski, Marek; Fátima Reis, M.; Namorado, Sónia; Gurzau, Anca Elena; Lupsa, Ioana Rodica; Halzlova, Katarina; Jajcaj, Michal; Mazej, Darja; Tratnik, Janja Snoj; López, Ana; Lopez, Estrella; Berglund, Marika; Larsson, Kristin; Lehmann, Andrea; Crettaz, Pierre; Schoeters, Greet, 2026, "First steps toward harmonized human biomonitoring in Europe: Demonstration project to perform human biomonitoring on a European scale [* Cross-Reference *]", https://lore.list.lu/citation?persistentId=perma:LIST.CQW4YL, LIST Open Repository, V1
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Background: For Europe as a whole, data on internal exposure to environmental chemicals do not yet exist. Characterization of the internal individual chemical environment is expected to enhance understanding of the environmental threats to health. objectives: We developed and applied a harmonized protocol to collect comparable human biomonitoring data all over Europe. Methods: In 17 European countries, we measured mercury in hair and cotinine, phthalate metabolites, and cadmium in urine of 1,844 children (5–11 years of age) and their mothers. Specimens were collected over a 5-month period in 2011–2012. We obtained information on personal characteristics, environment, and lifestyle. We used the resulting database to compare concentrations of exposure biomarkers within Europe, to identify determinants of exposure, and to compare exposure biomarkers with health-based guidelines. Results: Biomarker concentrations showed a wide variability in the European population. However, levels in children and mothers were highly correlated. Most biomarker concentrations were below the health-based guidance values. Conclusions: We have taken the frst steps to assess personal chemical exposures in Europe as a whole. Key success factors were the harmonized protocol development, intensive training and capacity building for feld work, chemical analysis and communication, as well as stringent quality control programs for chemical and data analysis. Our project demonstrates the feasibility of a Europe-wide human biomonitoring framework to support the decision-making process of environmental measures to protect public health. (2015-01-01)
***This entry has been automatically imported via Infodoc(ASO) CSV by LIST harvest scripts. Please refer to https://doi.org/10.1289/ehp.1408616 for the original and latest version of the dataset and data downloads*** (2026-06-08)
Subject Other
Keyword Europe, environmental, internal individual chemical, exposure, exposure biomarkers
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