The use of a complex tetra-culture alveolar model to study the biological effects induced by gold nanoparticles with different physicochemical properties [* Cross-Reference *]

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Saibene, Melissa; Serchi, Tommaso; Bonfanti, Patrizia; Colombo, Anita; Nelissen, Inge; Halder, Rashi; Audinot, Jean Nicolas; Pelaz, Beatriz; Soliman, Mahmoud G.; Parak, Wolfgang J.; Mantecca, Paride; Gutleb, Arno C.; Cambier, Sebastien, 2026, "The use of a complex tetra-culture alveolar model to study the biological effects induced by gold nanoparticles with different physicochemical properties [* Cross-Reference *]", https://lore.list.lu/citation?persistentId=perma:LIST.BVBOQN, LIST Open Repository, V1
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Description
A substantial increase in engineered nanoparticles in consumer products has been observed, heightening human and environmental exposure. Inhalation represents the primary route of human exposure, necessitating a focus on lung toxicity studies. However, to avoid ethical concerns the use of in vitro models is an efficient alternative to in vivo models. This study utilized an in vitro human alveolar barrier model at air-liquid-interface with four cell lines, for evaluating the biological effects of different gold nanoparticles. Exposure to PEGylated gold nanospheres, nanorods, and nanostars did not significantly impact viability after 24 h, yet all AuNPs induced cytotoxicity in the form of membrane integrity impairment. Gold quantification revealed cellular uptake and transport. Transcriptomic analysis identified gene expression changes, particularly related to the enhancement of immune cells. Despite limited impact, distinct effects were observed, emphasizing the influence of nanoparticles physicochemical parameters while demonstrating the model's efficacy in investigating particle biological effects. (2024-03-01)
***This entry has been automatically imported via Infodoc(ASO) CSV by LIST harvest scripts. Please refer to https://doi.org/10.1016/j.etap.2023.104353 for the original and latest version of the dataset and data downloads*** (2026-06-24)
Subject Earth and Environmental Sciences; Physics
Keyword Air-liquid-interface, Alveolar in vitro model, Gold nanoparticles, Transcriptomic
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