Peptide-reinforced, photocrosslinkable PEG-based hydrogels [* Cross-Reference *]

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Russell, Sam; Jang, Daseul; Thomas, Jessica; Grysan, Patrick; Sprandl, Linus; Biesalski, Markus; Korley, La Shanda T.J.; Bruns, Nico, 2026, "Peptide-reinforced, photocrosslinkable PEG-based hydrogels [* Cross-Reference *]", https://lore.list.lu/citation?persistentId=perma:LIST.AMFILV, LIST Open Repository, V1

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Description	Hydrogels are polymer networks that swell in aqueous solvents. These materials have applications in many fields, including drug delivery, tissue engineering, and soft robotics. For example, polyethylene glycol (PEG) diacrylate is often used as a light-curable crosslinker for the synthesis of PEG-based hydrogels, e.g., in bioinks for 3D printing. However, a common limitation of PEG hydrogels is their typically poor mechanical properties, particularly when in a swollen state. The mechanical strength of natural polymeric materials, such as spider silk and collagen, arises from the formation of hierarchical secondary protein structures that unfold under mechanical load. Here, we present a bio-inspired approach to reinforcing PEG-based hydrogels that mimics these hierarchical structures by incorporating poly(β-benzyl-l-aspartate) (PBLA) blocks between cross-linking end groups and PEG chain segments. We used this peptide-containing crosslinker in combination with a small hydrophilic comonomer, 2-hydroxyethyl acrylate, to synthesise PHEA-linked by-(PBLA-b-PEG-b-PBLA) co-networks with tailored compositions, yielding improved and tailorable mechanical properties. This approach affords hydrogels with increased strength and toughness while retaining the networks’ swelling ability. This research presents a promising avenue for developing robust photocrosslinkable hydrogels with broad practical applications. (2026-03-01) *This entry has been automatically imported via Infodoc(ASO) CSV by LIST harvest scripts. Please refer to https://doi.org/10.1039/d5lp00335k for the original and latest version of the dataset and data downloads* (2026-06-04)
Subject	Physics
Keyword	aqueous solvents, polymer networks, networks that swell, swell in aqueous, Hydrogels
License/Data Use Agreement	Custom Dataset Terms


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Persistent Identifier	perma:LIST.AMFILV
Publication Date	2026-07-06
Title	Peptide-reinforced, photocrosslinkable PEG-based hydrogels [* Cross-Reference *]
Other Identifier	https://doi.org/10.1039/d5lp00335k SCOPUS_ID:105029454340
Author	(Technische Universität Darmstadt, Technische Universität Darmstadt, University of Strathclyde)0000-0002-8906-4742 (University of Delaware College of Engineering)0000-0003-0138-4627 Thomas, Jessica (University of Delaware College of Engineering) (Luxembourg Institute of Science and Technology)0000-0003-2081-8267 Sprandl, Linus (Technische Universität Darmstadt) Biesalski, Markus (Technische Universität Darmstadt) (University of Delaware College of Engineering, University of Delaware College of Engineering)0000-0002-8266-5000 (Technische Universität Darmstadt, Technische Universität Darmstadt, University of Strathclyde)0000-0001-6199-9995
Point of Contact	Use email button above to contact. LIST RDS (LIST)
Description	Hydrogels are polymer networks that swell in aqueous solvents. These materials have applications in many fields, including drug delivery, tissue engineering, and soft robotics. For example, polyethylene glycol (PEG) diacrylate is often used as a light-curable crosslinker for the synthesis of PEG-based hydrogels, e.g., in bioinks for 3D printing. However, a common limitation of PEG hydrogels is their typically poor mechanical properties, particularly when in a swollen state. The mechanical strength of natural polymeric materials, such as spider silk and collagen, arises from the formation of hierarchical secondary protein structures that unfold under mechanical load. Here, we present a bio-inspired approach to reinforcing PEG-based hydrogels that mimics these hierarchical structures by incorporating poly(β-benzyl-l-aspartate) (PBLA) blocks between cross-linking end groups and PEG chain segments. We used this peptide-containing crosslinker in combination with a small hydrophilic comonomer, 2-hydroxyethyl acrylate, to synthesise PHEA-linked by-(PBLA-b-PEG-b-PBLA) co-networks with tailored compositions, yielding improved and tailorable mechanical properties. This approach affords hydrogels with increased strength and toughness while retaining the networks’ swelling ability. This research presents a promising avenue for developing robust photocrosslinkable hydrogels with broad practical applications. (2026-03-01) *This entry has been automatically imported via Infodoc(ASO) CSV by LIST harvest scripts. Please refer to https://doi.org/10.1039/d5lp00335k for the original and latest version of the dataset and data downloads* (2026-06-04)
Subject	Physics
Keyword	aqueous solvents polymer networks networks that swell swell in aqueous Hydrogels
Funding Information	National Science Foundation: OISE 1844463
Deposit Date	2026-03-01
Data Type	Article
Data Source	Rsc Applied Polymers; eISSN: 2755371X, vol. 4, n° 2, pp. 704-715, 2026

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