Aptamer-conjugated gold nanoparticles enable oligonucleotide delivery into muscle stem cells to promote regeneration of dystrophic muscles [* Cross-Reference *]

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Millozzi, Francesco; Milán-Rois, Paula; Sett, Arghya; Delli Carpini, Giovanni; De Bardi, Marco; Gisbert-Garzarán, Miguel; Sandonà, Martina; Rodríguez-Díaz, Ciro; Martínez-Mingo, Mario; Pardo, Irene; Esposito, Federica; Viscomi, Maria Teresa; Bouché, Marina; Parolini, Ornella; Saccone, Valentina; Toulmé, Jean Jacques; Somoza, Álvaro; Palacios, Daniela, 2026, "Aptamer-conjugated gold nanoparticles enable oligonucleotide delivery into muscle stem cells to promote regeneration of dystrophic muscles [* Cross-Reference *]", https://lore.list.lu/citation?persistentId=perma:LIST.7SCN05, LIST Open Repository, V1
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Description
Inefficient targeting of muscle stem cells (MuSCs), also called satellite cells, represents a major bottleneck of current therapeutic strategies for muscular dystrophies, as it precludes the possibility of promoting compensatory regeneration. Here we describe a muscle-targeting delivery platform, based on gold nanoparticles, that enables the release of therapeutic oligonucleotides into MuSCs. We demonstrate that AuNPs conjugation to an aptamer against α7/β1 integrin dimers directs either local or systemic delivery of microRNA-206 to MuSCs, thereby promoting muscle regeneration and improving muscle functionality, in a mouse model of Duchenne Muscular Dystrophy. We show here that this platform is biocompatible, non-toxic, and non-immunogenic, and it can be easily adapted for the release of a wide range of therapeutic oligonucleotides into diseased muscles. (2025-12-01)
***This entry has been automatically imported via Infodoc(ASO) CSV by LIST harvest scripts. Please refer to https://doi.org/10.1038/s41467-024-55223-9 for the original and latest version of the dataset and data downloads*** (2026-06-09)
Subject Earth and Environmental Sciences
Keyword called satellite cells, current therapeutic strategies, muscle stem cells, stem cells, satellite cells
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