Top-Down Fabricated Silicon Nanowire Arrays for Field-Effect Detection of Prostate-Specific Antigen [* Cross-Reference *]

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Rani, Dipti; Pachauri, Vivek; Madaboosi, Narayanan; Jolly, Pawan; Vu, Xuan Thang; Estrela, Pedro; Chu, Virginia; Conde, João Pedro; Ingebrandt, Sven, 2018, "Top-Down Fabricated Silicon Nanowire Arrays for Field-Effect Detection of Prostate-Specific Antigen [* Cross-Reference *]", https://lore.list.lu/citation?persistentId=perma:LIST.4GGCJZ, LIST Open Repository, V1
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Description
Highly sensitive electrical detection of biomarkers for the early stage screening of cancer is desired for future, ultrafast diagnostic platforms. In the case of prostate cancer (PCa), the prostate-specific antigen (PSA) is of prime interest and its detection in combination with other PCa-relevant biomarkers in a multiplex approach is advised. Toward this goal, we demonstrate the label-free, potentiometric detection of PSA with silicon nanowire ion-sensitive field-effect transistor (Si NW-ISFET) arrays. To realize the field-effect detection, we utilized the DNA aptamer-receptors specific for PSA, which were covalently and site-specifically immobilized on Si NW-ISFETs. The platform was used for quantitative detection of PSA and the change in threshold voltage of the Si NW-ISEFTs was correlated with the concentration of PSA. Concentration-dependent measurements were done in a wide range of 1 pg/mL to 1 μg/mL, which covers the clinical range of interest. To confirm the PSA-DNA aptamer binding on the Si NW surfaces, a sandwich-immunoassay based on chemiluminescence was implemented. The electrical approach using the Si NW-ISFET platform shows a lower limit of detection and a wide dynamic range of the assay. In future, our platform should be utilized to detect multiple biomarkers in one assay to obtain more reliable information about cancer-related diseases. (2018-08-31)
***This entry has been automatically imported via Infodoc(ASO) CSV by LIST harvest scripts. Please refer to https://doi.org/10.1021/acsomega.8b00990 for the original and latest version of the dataset and data downloads*** (2026-06-10)
Subject Physics
Keyword early stage screening, ultrafast diagnostic platforms, Highly sensitive electrical, Highly sensitive, ultrafast diagnostic
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