Design specifications for biomedical virtual twins in engineered adoptive cellular immunotherapies [* Cross-Reference *]

Version 1.0
Ulrike Weirauch; Markus Kreuz; Colin Birkenbihl; Miriam Alb; Maria Quaranta; Laurence Calzone; Sophia Orozco-Ruiz; Stefanie Binder; Luise Fischer; Solène Clavreul; Morine Maguri; Maximilian Ferle; Michael Rade; Guillaume Azarias; Jay R. Hydren; Jakub Jamárik; Dániel Schwarz; Zsolt Sebestyén; Jürgen Kuball; Georg Popp; Chloé Antoine; Manon Knockaert; Clara T. Schoeder; David Fandrei; Carmen Sanges; Vaclovas Radvilas; Nico Gagelmann; Markus Rückert; Olaf Penack; Stephan Fricke; Andreas Schmidt; Carol Ward; Carl Steinbeißer; Jean-Marc Van Gyseghem; Anna Niarakis; Laurent Garderet; Michael Hudecek; Thomas Neumuth; Uwe Platzbecker; Ulrike Koehl; Regina Demlová; Andreas Kremer; Stefan Franke; Holger Fröhlich; Maximilian Merz; Kristin Reiche; Maximilian Ferle; Jean-Marc Van Gyseghem; Ulrike Köhl, 2026, "Design specifications for biomedical virtual twins in engineered adoptive cellular immunotherapies [* Cross-Reference *]", https://lore.list.lu/citation?persistentId=perma:LIST.2LT2QM, LIST Open Repository, V1
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Description
In (immune)oncology, virtual twins (VTs) offer patient-individual decision support. Nevertheless, current VTs do not incorporate the unique properties of engineered adoptive cellular immunotherapies (eACIs). Here, we outline the minimal design specifications for VTs for engineered ACIs (eACI-VTs) to model the complex interplay between cell product and patient physiology. We motivate utilizing VTs in eACIs to provide decision support and reflect on how eACI-VTs can support the widespread use of eACIs. (2025-08-01)
***This entry has been automatically imported via OpenAlex by LIST harvest scripts. Please refer to https://doi.org/10.1038/s41746-025-01809-6 for the original and latest version of the publication*** (2026-07-01)
Subject Chemistry; Engineering; Medicine, Health and Life Sciences; Physics
Keyword Immune system, Computer science, Computational biology, Adoptive cell transfer, Psychology, Neuroscience, Human–computer interaction, Medicine, Biology, Immunology, T cell
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