Long‐Term Outcomes After Cardiac Arrest: Protocol for the Extended Follow‐Up Sub‐Study of the STEPCARE Trial [* Cross-Reference *]

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Gisela Lilja; Dorit Töniste; Frances Bass; Janus Christian Jakobsen; Niklas Nielsen; Markus B. Skrifvars; Susann Ullén; Josef Dankiewicz; Helena Levin; Johanna Hästbacka; Marion Moseby‐Knappe; Manoj Saxena; Matt P. Wise; Paul J. Young; Anders Åneman; Koen Ameloot; Jade Cole; Tobias Cronberg; Anthony Delaney; Patrick Druwé; Joachim Düring; Tobias Graf; Matthias Hænggi; Katarina Heimburg; Manuela Itens; Caroline Barkholt Kamp; Thomas Keeble; Christoph Leithner; Anna Lybeck; Andreas Lundin; Peter J. McGuigan; Annerose Mengel; Tuomas Oksanen; John P. Ridgway; Luis Romundstad; Claudia Schrag; Pascal Stammet; Anna Tippett; Matthew Thomas; Joonas Tirkkonen; Johan Undén; Balasubramanian Venkatesh; Marjaana Tiainen; Naomi Hammond, 2026, "Long‐Term Outcomes After Cardiac Arrest: Protocol for the Extended Follow‐Up Sub‐Study of the STEPCARE Trial [* Cross-Reference *]", https://lore.list.lu/citation?persistentId=perma:LIST.0MBKZA, LIST Open Repository, V1

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Description	Background: The international multi-center randomized controlled STEPCARE-trial will investigate optimal management of sedation, temperature, and mean arterial pressure (MAP) during intensive care in out-of-hospital cardiac arrest (OHCA) patients due to various etiologies. The primary outcome is mortality at 6 months. This protocol describes an extended follow-up sub-study of the STEPCARE-trial with the main objective to provide detailed long-term outcomes for survivors and caregivers. It will focus on potential neuroprotection and improved recovery for different targets of sedation, temperature, and MAP management at 6 and 12 months post-OHCA. Methods: All survivors and one caregiver per survivor at selected STEPCARE sites will be invited to participate. Randomization is stratified by site. This sub-study extends the main STEPCARE follow-up at 6 months by undertaking detailed assessments, face-to-face meetings, inclusion of a caregiver, and repeating the assessments at 12 months. Our main outcome for survivors is cognitive function measured by the Montreal Cognitive Assessment, and for caregivers, the caregiver burden measured by the Zarit Burden Interview. Additional outcomes include symptoms of anxiety, depression, post-traumatic stress disorder, fatigue, physical function, life satisfaction, and life impact (disability), assessed by psychometrically robust measures. The estimated sample size is 600. Efforts to improve interrater reliability and decrease missing data are integral to the study design. Conclusion: These detailed long-term outcomes will explore the possible benefits or risks of fever, sedation, and blood pressure management in post-OHCA survivors. Additionally, this study will explore survivorship after cardiac arrest from various perspectives, including different causes of arrest. ClinicalTrials.gov: NCT0207942. (2025-08-26) *This entry has been automatically imported via OpenAlex by LIST harvest scripts. Please refer to https://doi.org/10.1111/aas.70114 for the original and latest version of the publication* (2026-07-01)
Subject	Medicine, Health and Life Sciences
Keyword	Medicine, Caregiver burden, Anxiety, Randomized controlled trial, Sedation, Physical therapy, Quality of life (healthcare), Emergency medicine, Psychiatry, Dementia, Internal medicine, Surgery
License/Data Use Agreement	Custom Dataset Terms


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Citation Metadata

Persistent Identifier	perma:LIST.0MBKZA
Publication Date	2026-07-06
Title	Long‐Term Outcomes After Cardiac Arrest: Protocol for the Extended Follow‐Up Sub‐Study of the STEPCARE Trial [* Cross-Reference *]
Other Identifier	https://doi.org/10.1111/aas.70114 OpenAlex ID: https://openalex.org/W4413621160
Author	Gisela Lilja (Lund University, Skåne University Hospital) - ORCID: https://orcid.org/0000-0003-1860-1456 Dorit Töniste (Lund University, Skåne University Hospital) Frances Bass (Royal North Shore Hospital, The George Institute for Global Health) - ORCID: https://orcid.org/0000-0003-3826-8558 Janus Christian Jakobsen (University of Southern Denmark, Copenhagen University Hospital) - ORCID: https://orcid.org/0000-0002-3642-2120 Niklas Nielsen (Lund University, Helsingborgs lasarett) - ORCID: https://orcid.org/0000-0002-6013-126X Markus B. Skrifvars (University of Helsinki, Helsinki University Hospital) - ORCID: https://orcid.org/0000-0002-0341-0262 Susann Ullén (Skåne University Hospital) - ORCID: https://orcid.org/0000-0003-4854-9230 Josef Dankiewicz (Lund University, Skåne University Hospital) - ORCID: https://orcid.org/0000-0002-6312-6749 Helena Levin (Lund University, Skåne University Hospital, Innovation Skåne (Sweden)) - ORCID: https://orcid.org/0000-0002-1883-3954 Johanna Hästbacka (Tampere University, Pirkanmaa Hospital District, Tampere University Hospital, Tampere University) - ORCID: https://orcid.org/0000-0002-3613-7231 Marion Moseby‐Knappe (Lund University, Skåne University Hospital) - ORCID: https://orcid.org/0000-0001-8160-5957 Manoj Saxena (UNSW Sydney, The George Institute for Global Health, St George Hospital) - ORCID: https://orcid.org/0000-0002-0385-6731 Matt P. Wise (University Hospital of Wales) - ORCID: https://orcid.org/0000-0002-2763-4316 Paul J. Young (The University of Melbourne, Wellington Hospital, Australian and New Zealand Intensive Care Society, Medical Research Institute of New Zealand, Monash University) - ORCID: https://orcid.org/0000-0002-3428-3083 Anders Åneman (Liverpool Hospital, UNSW Sydney, Ingham Institute, South Western Sydney Local Health District) - ORCID: https://orcid.org/0000-0003-2096-5304 Koen Ameloot (Ziekenhuis Oost-Limburg) - ORCID: https://orcid.org/0000-0001-7071-8825 Jade Cole (University Hospital of Wales) Tobias Cronberg (Lund University, Skåne University Hospital) - ORCID: https://orcid.org/0000-0002-3442-3058 Anthony Delaney (The University of Sydney, Royal North Shore Hospital, The George Institute for Global Health, Northern Sydney Local Health District) - ORCID: https://orcid.org/0000-0002-1015-7146 Patrick Druwé (Lund University, Skåne University Hospital) - ORCID: https://orcid.org/0000-0001-8776-6591 Joachim Düring (Ghent University Hospital) - ORCID: https://orcid.org/0000-0003-1538-9824 Tobias Graf (German Centre for Cardiovascular Research, University of Lübeck) - ORCID: https://orcid.org/0000-0003-4038-147X Matthias Hænggi (University Hospital of Zurich) - ORCID: https://orcid.org/0000-0001-5845-031X Katarina Heimburg (Lund University, Skåne University Hospital) - ORCID: https://orcid.org/0000-0002-2586-1638 Manuela Itens (University Hospital of Bern) Caroline Barkholt Kamp (Copenhagen University Hospital) - ORCID: https://orcid.org/0000-0002-7756-4694 Thomas Keeble (Essex Cardiothoracic Centre, Anglia Ruskin University) - ORCID: https://orcid.org/0000-0001-8695-7994 Christoph Leithner (Humboldt-Universität zu Berlin) - ORCID: https://orcid.org/0000-0002-8277-846X Anna Lybeck (Lund University, Skåne University Hospital) - ORCID: https://orcid.org/0000-0001-7574-3958 Andreas Lundin (University of Gothenburg) - ORCID: https://orcid.org/0000-0002-6623-6847 Peter J. McGuigan (Queen's University Belfast, University of Ulster, Royal Victoria Hospital) - ORCID: https://orcid.org/0000-0001-5766-990X Annerose Mengel (STZ eyetrial, University of Tübingen) - ORCID: https://orcid.org/0000-0002-2399-3020 Tuomas Oksanen (University of Helsinki, Helsinki University Hospital) John P. Ridgway (St Bartholomew's Hospital, Barts Health NHS Trust) Luis Romundstad (Oslo University Hospital) - ORCID: https://orcid.org/0000-0003-0552-1668 Claudia Schrag (University of St.Gallen) Pascal Stammet (Centre Hospitalier de Luxembourg, Luxembourg Institute of Science and Technology, Arbed (Luxembourg)) - ORCID: https://orcid.org/0000-0002-0298-1012 Anna Tippett (The George Institute for Global Health) Matthew Thomas (University of the West of England, University Hospitals Bristol NHS Foundation Trust, Bristol Hospital) - ORCID: https://orcid.org/0000-0002-3299-3495 Joonas Tirkkonen (Pirkanmaa Hospital District, Tampere University Hospital, Tampere University) - ORCID: https://orcid.org/0000-0001-7081-4227 Johan Undén (Lund University, Hallands sjukhus Halmstad) - ORCID: https://orcid.org/0000-0002-8344-5720 Balasubramanian Venkatesh (Gold Coast Hospital, The George Institute for Global Health) - ORCID: https://orcid.org/0000-0002-3234-5244 Marjaana Tiainen (University of Helsinki, Helsinki University Hospital) - ORCID: https://orcid.org/0000-0001-5107-1990 Naomi Hammond (Royal North Shore Hospital, The George Institute for Global Health) - ORCID: https://orcid.org/0000-0002-6559-7747
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Description	Background: The international multi-center randomized controlled STEPCARE-trial will investigate optimal management of sedation, temperature, and mean arterial pressure (MAP) during intensive care in out-of-hospital cardiac arrest (OHCA) patients due to various etiologies. The primary outcome is mortality at 6 months. This protocol describes an extended follow-up sub-study of the STEPCARE-trial with the main objective to provide detailed long-term outcomes for survivors and caregivers. It will focus on potential neuroprotection and improved recovery for different targets of sedation, temperature, and MAP management at 6 and 12 months post-OHCA. Methods: All survivors and one caregiver per survivor at selected STEPCARE sites will be invited to participate. Randomization is stratified by site. This sub-study extends the main STEPCARE follow-up at 6 months by undertaking detailed assessments, face-to-face meetings, inclusion of a caregiver, and repeating the assessments at 12 months. Our main outcome for survivors is cognitive function measured by the Montreal Cognitive Assessment, and for caregivers, the caregiver burden measured by the Zarit Burden Interview. Additional outcomes include symptoms of anxiety, depression, post-traumatic stress disorder, fatigue, physical function, life satisfaction, and life impact (disability), assessed by psychometrically robust measures. The estimated sample size is 600. Efforts to improve interrater reliability and decrease missing data are integral to the study design. Conclusion: These detailed long-term outcomes will explore the possible benefits or risks of fever, sedation, and blood pressure management in post-OHCA survivors. Additionally, this study will explore survivorship after cardiac arrest from various perspectives, including different causes of arrest. ClinicalTrials.gov: NCT0207942. (2025-08-26) *This entry has been automatically imported via OpenAlex by LIST harvest scripts. Please refer to https://doi.org/10.1111/aas.70114 for the original and latest version of the publication* (2026-07-01)
Subject	Medicine, Health and Life Sciences
Keyword	Medicine Caregiver burden Anxiety Randomized controlled trial Sedation Physical therapy Quality of life (healthcare) Emergency medicine Psychiatry Dementia Internal medicine Surgery
Topic Classification	Cardiac Arrest and Resuscitation Intensive Care Unit Cognitive Disorders Family and Patient Care in Intensive Care Units
Deposit Date	2025-08-26
Data Type	Article
Data Source	Acta Anaesthesiologica Scandinavica

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